This study focuses on the drawings of items collected during D.G. Messerschmidt’s fi rst multidisciplinary expedition to Siberia in 1719–1727. Pictures of the artifacts have been preserved among the documents held by the Academy of Sciences Archive in the personal papers of the traveler, which includes his fi eld journals, the appendices of his reports to the Pharmaceutical (Medical) Registry, and a large handwritten treatise “Sibiria Perlustrata” (1727), outlining the expedition’s fi ndings. In 1728, Messerschmidt’s archaeological collection was included as part of Peter the Great’s Siberian Collection, exhibited at the Kunstkamera. Watercolor and pencil drawings and engravings depicting the exhibits are identifi ed. Handwritten descriptions and drawings of the items have made it possible to a certain extent to reconstruct the fi rst encyclopedist’s Siberian archaeological collection, which perished during the 1747 fi re at the Kunstkamera. As Messerschmidt’s graphic works demonstrate, he documented items spanning the time from the Bronze Age to the Late Middle Ages and covering the territory from the Urals to the Trans-Baikal region, including things imported from Western Europe, China, and Central Asia. Also, he collected archaeological items representing virtually all cultures of the Minusinsk Basin. It is concluded that in the fi rst third of the 18th century, Messerschmidt’s collection was the world’s largest and most representative assemblage of artifacts from northeastern Eurasia.