Academician A.P. Derevianko’s longterm studies are summarized in the fi rst four volumes of his monograph on three global human migrations in Eurasia. The routes whereby early humans dispersed from Africa and eventually spread over nearly entire Eurasia are reconstructed, and numerous empirical and theoretical problems stemming from these reconstructions are convincingly resolved. Derevianko headed the excavations of Paleolithic sites scattered across vast territories of Asia. Especially important are the discoveries in the Altai. This work has raised a number of questions of key importance, for which no universally accepted answers have been given so far. Based on the hominin fossil record and having critically examined the principal hypotheses and proposals concerning both biological and cultural aspects of human evolution, A.P. Derevianko has come up with his own theory of the origin of the genus Homo, originating from Australopithecines. Some groups of the latter are believed to have been mentally predisposed for developing cumulative knowledge relating to lithic technologies and other aspects of culture. One of these aspects is the behavior relating to the interment of the dead—the fi rst specifi cally human cultural trait, documented since the fi nal Acheulean. Human migrations involve a plexus of issues: properties of the raw material affecting lithic industries, and the extreme environmental variability peculiar to the largest continent. Despite the exponential growth of publications addressing human evolution, Derevianko’s conclusions, both empirical and theoretical, outlined in the fi rst volumes of his summarizing work, retain a key importance.