We reconstruct environmental conditions at various stages of the Late Pleistocene and Early Holocene of East Kazakhstan. The reconstructions are based on materials from the stratified Ushbulak site in the Shilikta Valley, spanning a period from the Early Upper Paleolithic to the Bronze Age. Climatic changes were evaluated using natural science methods-mineralogical, ZooArchaeology by Mass Spectrometry (ZooMS), OSL- and AMS-dating, etc. Sevaral stages, relating to environmental changes, are evaluated. The fi rst period (~52–37 ka BP) was period of moderately warm and relatively humid climate, with predominantly forest-steppe, meadow-steppe, and semidesert landscapes. The second period (~25–21 ka BP) coincided with a transition from a moderately warm to a very cold and more arid climate dominated by steppes. The third period (~18–16 ka BP) was transitional from the glacial maximum to the postglacial interstadial, with a relatively cool and arid climate and mostly steppe and forest-steppe landscapes. The fourth period (~15–14 ka BP) was characterized by the warmest climate in the Late Pleistocene; steppe and forest-steppe vegetation dominated. During the latest, Early Holocene period, the climate was warm and humid, with savanna-like landscapes. The analysis of natural-climatic conditions allows us to conclude that the early stage of the site’s functioning, characterized by the highest intensity of settlement, was optimal for ancient man.