This study continues a series of articles published in two last issues of this journal, exploring the split of the ancestral species H. heidelbergensis ~400 ka BP in the Levant and the subsequent origin of two filial species, Neanderthals and Denisovans. Certain members of H. heidelbergensis had moved to Europe, where a new taxon, H. s. neanderthalensis, emerged 200–150 ka BP. Others had migrated to Central Asia via Iran ~400–350 ka BP. Their assimilation of native populations of H. erectus, adaptation to changing environments, and natural selection led to the emergence of H. s. denisovan. In Uzbekistan, no Early Paleolithic sites are known. Based on archaeological evidence, one can presume that this territory was first peopled by Denisovans, who had migrated there from Tajikistan during MIS 6. At the final stage of the Karatau culture in Tajikistan, associated with pedocomplex 4 (MIS 11), new elements appeared in primary lithic reduction, types of stone tools, and the ways they were fashioned. In Uzbekistan, excavations of two key sites, Kulbulak and Obi-Rakhmat, have been ongoing for over five decades. Owing to long stratigraphic sequences, the evolution of the Middle Paleolithic industry of Denisovans has been traced over a long period spanning MIS 7–3. The only cave site excavated in Central Asia to-date, is Teshik-Tash in Uzbekistan, where Neanderthal fossils were found together with a Mousterian industry.